Research Articles:
Mroz NM, Chiaranunt P, Molofsky AV*, Molofsky AB*. Cross-regulation between the nervous system and type 2 immunity. Sci Immunol. 2025 May 16;10(107):eadp6450. doi: 10.1126/sciimmunol.adp6450. Epub 2025 May 16. Review. PubMed PMID: 40378238. *co-corresponding
Merrill ED, Prudent V, Moghadam P, Rodriguez A, Hurabielle C, Wells EKC, Basso P, Scharschmidt TC, Rosenblum MD, Molofsky AB*, Noble SM*. The emerging fungal pathogen Candida auris induces IFNγ to colonize mammalian hair follicles. bioRxiv. 2025 Jan 18;. doi: 10.1101/2025.01.15.632653. PubMed PMID: 39868197; PubMed Central PMCID: PMC11760791. *co-corresponding
Ewing-Crystal NA, Mroz NM, Chang AA, Merrill ED, Caryotakis SE, Teo L, Larpthaveesarp A, Tsukui T, Katewa A, Pennington R, McKinsey GL, Nelson S, Ciesielska A, Dahlgren MW, Paidassi H, Jain S, Aghi MK, Bourne JA, Paz JT, Gonzalez FF, Sheppard D, Molofsky AV, Arnold TD*, Molofsky AB*. Dynamic fibroblast-immune interactions shape wound healing after brain injury. bioRxiv. 2024 Mar 15;. doi: 10.1101/2024.03.13.584873. PubMed PMID: 40093059; PubMed Central PMCID: PMC11908209. *co-corresponding
Nyberg WA, Wang CH, Ark J, Liu C, Clouden S, Qualls A, Caryotakis S, Wells E, Simon K, Garza C, Bernard PL, Lopez-Ichikawa M, Li Z, Seo J, Kimmerly GR, Muldoon JJ, Chen PA, Li M, Liang HE, Kersten K, Rosales A, Kuhn N, Ye CJ, Gardner JM, Molofsky AB, Ricardo-Gonzalez RR, Asokan A, Eyquem J. In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313. Immunity. 2025 Feb 11;58(2):499-512.e7. doi: 10.1016/j.immuni.2025.01.009. Epub 2025 Feb 4. PubMed PMID: 39909036.
Kumar R, Nolan K, Kassa B, Chanana N, Palmo T, Sharma K, Singh K, Mickael C, Fonseca Balladares D, Nilsson J, Prabhakar A, Mishra A, Lee MH, Sanders L, Kumar S, Molofsky AB, Stenmark KR, Sheppard D, Tuder RM, Gupta MD, Thinlas T, Pasha Q, Graham BB. Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension. J Clin Invest. 2025 Jan 30;135(6). doi: 10.1172/JCI176865. PubMed PMID: 39883518; PubMed Central PMCID: PMC11910231.
Barron JJ, Mroz NM, Taloma SE, Dahlgren MW, Ortiz-Carpena JF, Keefe MG, Escoubas CC, Dorman LC, Vainchtein ID, Chiaranunt P, Kotas ME, Nowakowski TJ, Bender KJ, Molofsky AB*, Molofsky AV.* Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior. Science. 2024 Nov;386(6721). PMID: 39480923. *co-corresponding
Mroz NM*, Ciesielska A*, Ewing-Crystal NA, Dorman LC, Han RT, Barron JJ, Silva NJ, Molofsky AV, Molofsky AB#, Paz JT#. Type 1 lymphocytes and interferon-γ accumulate in the thalamus and restrict seizure susceptibility after traumatic brain injury. bioRxiv. 2024 Dec 28;. doi: 10.1101/2024.12.28.630606. PubMed PMID: 39763918; PMC11703260. #co-corresponding, *authors contributed equally
Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Barron JJ, Wade SD, Cuevas B, Vainchtein ID, Silva NJ, Guajardo R, Xiao Y, Lidsky PV, Wang EY, Rivera BM, Taloma SE, Kim DK, Kaminskaya E, Nakao-Inoue H, Schwer B, Arnold TD, Molofsky AB, Condello C, Andino R, Nowakowski TJ, Molofsky AV. Type-I-interferon-responsive microglia shape cortical development and behavior. Cell. 2024 Apr 11;187(8):1936-1954.e24. PMC11015974.
Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB. Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis. bioRxiv. 2023 Apr 28. PMID: 37163060; PMC10168323.
Molofsky AB, Locksley RM. The ins and outs of innate and adaptive type 2 immunity. Immunity. 2023 Apr 11;56(4):704-722. doi: 10.1016/j.immuni.2023.03.014. Review. PubMed PMID: 37044061; PubMed Central PMCID: PMC10120575.
Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB*, Peng T*. Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir. Immunity. 2023 Mar 14;56(3):576-591.e10. doi: 10.1016/j.immuni.2023.01.032. Epub 2023 Feb 22. PubMed PMID: 36822205; PubMed Central PMCID: PMC10578134. *co-corresponding
Siewiera J, McIntyre TI, Cautivo KM, Mahiddine K, Rideaux D, Molofsky AB, Erlebacher A. Circumvention of luteolysis reveals parturition pathways in mice dependent upon innate type 2 immunity. Immunity. 2023 Mar 14;56(3):606-619.e7. doi: 10.1016/j.immuni.2023.01.005. Epub 2023 Feb 6. PubMed PMID: 36750100; PubMed Central PMCID: PMC10023352.
Han RT, Vainchtein ID, Schlachetzki JCM, Cho FS, Dorman LC, Ahn E, Kim DK, Barron JJ, Nakao-Inoue H, Molofsky AB, Glass CK, Paz JT, Molofsky AV. Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice. J Exp Med. 2023 Feb 6;220(2). doi: 10.1084/jem.20220605. Epub 2022 Dec 15. PubMed PMID: 36520518; PubMed Central PMCID: PMC9757845.
Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. Immunity. 2022 Feb 8;55(2):254-271.e7. doi: 10.1016/j.immuni.2021.12.014. PubMed PMID: 35139352; PubMed Central PMCID: PMC8852844.
Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky AB, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T. Sentinel p16(INK4a+) cells in the basement membrane form a reparative niche in the lung. Science. 2022 Oct 14;378(6616):192-201. doi: 10.1126/science.abf3326. Epub 2022 Oct 13. PubMed PMID: 36227993; PubMed Central PMCID: PMC10621323.
O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM. Bile acid-sensitive tuft cells regulate biliary neutrophil influx. Sci Immunol. 2022 Mar 4;7(69):eabj1080. doi: 10.1126/sciimmunol.abj1080. Epub 2022 Mar 4. PubMed PMID: 35245089; PubMed Central PMCID: PMC9166270.
Boothby IC, Kinet MJ, Boda DP, Kwan EY, Clancy S, Cohen JN, Habrylo I, Lowe MM, Pauli M, Yates AE, Chan JD, Harris HW, Neuhaus IM, McCalmont TH, Molofsky AB, Rosenblum MD. Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin. Nature. 2021 Nov;599(7886):667-672. doi: 10.1038/s41586-021-04044-7. Epub 2021 Oct 27. PubMed PMID: 34707292; PubMed Central PMCID: PMC8906225.
Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI. Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice. Elife. 2021 Oct 15;10. doi: 10.7554/eLife.69056. PubMed PMID: 34652270; PubMed Central PMCID: PMC8639143.
Nguyen PT, Dorman LC, Pan S, Vainchtein ID, Han RT, Nakao-Inoue H, Taloma SE, Barron JJ, Molofsky AB, Kheirbek MA, Molofsky AV. Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity. Cell. 2020 Jul 23;182(2):388-403.e15. doi: 10.1016/j.cell.2020.05.050. Epub 2020 Jul 1. PubMed PMID: 32615087; PubMed Central PMCID: PMC7497728.
Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky AB, Sheppard D, Chapman H, Peng T. Gli1(+) mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nat Cell Biol. 2020 Nov;22(11):1295-1306. doi: 10.1038/s41556-020-00591-9. Epub 2020 Oct 12. PubMed PMID: 33046884; PubMed Central PMCID: PMC7642162.
Dahlgren MW*, Jones SW*, Cautivo KM, Dubinin A, Farhat S, Ortiz-Carpena JF, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB. (2019). Adventitial stromal cells define group 2 innate lymphoid cell tissue niches. Immunity, 2019, 50, 707-722.e6. *authors contributed equally
Cameron GJM, Cautivo KM, Loering S, Jiang SH, Deshpande AV, Foster PS, McKenzie ANJ, Molofsky AB, Hansbro PM, Starkey MR. Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury. Front Immunol. 2019;10:826. doi: 10.3389/fimmu.2019.00826. eCollection 2019. Review. PubMed PMID: 31057549; PubMed Central PMCID: PMC6477147.
Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM. Tissue signals imprint ILC2 identity with anticipatory function. Nat Immunol. 2018 Oct;19(10):1093-1099. doi: 10.1038/s41590-018-0201-4. Epub 2018 Sep 10. PubMed PMID: 30201992; PubMed Central PMCID: PMC6202223.
Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB*, Molofsky AV*. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science. 2018 Mar 16;359(6381):1269-1273. doi: 10.1126/science.aal3589. Epub 2018 Feb 1. PubMed PMID: 29420261; PubMed Central PMCID: PMC6070131. *co-corresponding
Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Halliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM (2016). A tissue checkpoint regulates type 2 immunity. Nat Immunol. 12m 1381-1387.
Molofsky, A.B., Van Gool, F., Liang, H.-E., Van Dyken, S.J., Nussbaum, J.C., Lee, J., Bluestone, J.A., and Locksley, R.M. (2015). Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity 43, 1-14.
Lee, M.-W., Odegaard, J.I., Mukundan, L., Qiu, Y., Molofsky, A.B., Nussbaum, J.C., Yun, K., Locksley, R.M., and Chawla, A. (2015). Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell 160, 74–87.
Van Gool, F.*, Molofsky, A.B.*, Morar, M.M., Rosenzwajg, M., Liang, H.-E., Klatzmann, D., Locksley, R.M., and Bluestone, J.A. (2014). Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood 124, 3572–3576. *authors contributed equally
Dawson, A.L., LeBoit, P.E., Molofsky, A.B., Ai, W.Z., and Pincus, L.B. (2014). Peripheral T-Cell Lymphoma, Not Otherwise Specified Presenting as Erythroderma. Pathology Case Reviews 19, 221–226.
Van Dyken, S. J. Mohapatra, A., Nussbaum, J.C., Molofsky, A.B., Thornton, E.E., Ziegler, S.F., McKenzie, A.N., Krummel, M.F., Liang, H.E., Locksley, R.M. (2014). Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells. Immunity 40, 414–424.
Nussbaum J.C., Van Dyken S.J., Von Moltke J, Cheng L.E., Mohapatra A., Molofsky A.B., Thornton E.E., Krummel M.F., Chawla A., Liang H.E., Locksley R.M. (2013). Type 2 innate lymphoid cells control eosinophil homeostasis. Nature 502, 245–248.
Molofsky, A. B., Nussbaum, J. C., Liang, H.-E., Van Dyken, S. J., Cheng, L. E., Mohapatra, A., Chawla, A., Locksley R.M. (2013). Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. Journal of Experimental Medicine, 210(3), 535–549.
Rollins, M. D., Molofsky, A. B., Nambiar, A., Pandey, S., Weiskopf, R. B., & Toy, P. (2012). Two septic transfusion reactions presenting as transfusion-related acute lung injury from a split plateletpheresis unit. Critical care medicine, 40(8), 2488–2491.
Wu, D., Molofsky, A. B., Liang, H.-E., Ricardo-Gonzalez, R. R., Jouihan, H. A., Bando, J. K., Chawla, A., Locksley, R.M. (2011). Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science, 332(6026), 243–247.
Molofsky, A. B., Byrne, B. G., Whitfield, N. N., Madigan, C. A., Fuse, E. T., Tateda, K., & Swanson, M. S. (2006). Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. The Journal of Experimental Medicine, 203(4), 1093–1104.
Molofsky, A. B., Shetron-Rama, L. M., & Swanson, M. S. (2005). Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death. Infection and immunity, 73(9), 5720–5734.
Molofsky, A. B., & Swanson, M. S. (2003). Legionella pneumophila CsrA is a pivotal repressor of transmission traits and activator of replication. Mol Microbiol, 50(2), 445–461.
Patterson, K., Molofsky, A. B., Robinson, C., Acosta, S., Cater, C., & Fischer, J. A. (2004). The functions of Klarsicht and nuclear lamin in developmentally regulated nuclear migrations of photoreceptor cells in the Drosophila eye. Molecular biology of the cell, 15(2), 600–610.
Review articles and Book chapters:
Ricardo-Gonzalez RR, Molofsky AB, Locksley RM. ILC2s - development, divergence, dispersal. Curr Opin Immunol. 2022 Apr;75:102168. doi: 10.1016/j.coi.2022.102168. Epub 2022 Feb 14. Review. PubMed PMID: 35176675; PubMed Central PMCID: PMC9131705.
Sbierski-Kind J, Mroz N, Molofsky AB. Perivascular stromal cells: Directors of tissue immune niches. Immunol Rev. 2021 Jul;302(1):10-31. doi: 10.1111/imr.12984. Epub 2021 Jun 1. Review. PubMed PMID: 34075598.
Cautivo KM, Steer CA, Molofsky AB. Immune outposts in the adventitia: One foot in sea and one on shore. Curr Opin Immunol. 2020 Jun;64:34-41. doi: 10.1016/j.coi.2020.03.005. Epub 2020 Apr 24. Review. PubMed PMID: 32339862; PubMed Central PMCID: PMC7584777.
Molofsky AB, Locksley RM. Tissue immunity broadcasts near and far. Nat Rev Immunol. 2020 Feb;20(2):93-94. doi: 10.1038/s41577-019-0250-4. Review. PubMed PMID: 31748703.
Dahlgren MW, Molofsky AB. Adventitial Cuffs: Regional Hubs for Tissue Immunity. Trends Immunol. 2019 Oct;40(10):877-887. doi: 10.1016/j.it.2019.08.002. Epub 2019 Sep 13. Review. PubMed PMID: 31522963; PubMed Central PMCID: PMC6823140.
Dahlgren MW, Molofsky AB. All along the watchtower: group 2 innate lymphoid cells in allergic responses. Curr Opin Immunol. 2018 Oct;54:13-19. doi: 10.1016/j.coi.2018.05.008. Epub 2018 Jun 1. Review. PubMed PMID: 29860003; PubMed Central PMCID: PMC6460905.
Cautivo, K.M., Molofsky, A.B. (2016). Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells. Eur. J. Immunol. 1–31.
Guigas, B., Molofsky, A.B. (2015). A worm of one's own: how helminths modulate host adipose tissue function and metabolism. Trends Parasitol. 31, 435–441.
Molofsky, A.B., Savage, A.K., and Locksley, R.M. (2015). Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. Immunity 42, 1005–1019.
Molofsky, A.B. and Siddiqi, I.N. (2011). Case studies in hematology and coagulation: a new ASCP case set. Book chapter contributors for “Chronic myelogenous leukemia” and “Chronic neutrophilic leukemia”, Gulati, G., Flicko-O’Hara, J., and Krause, J.R. eds, American Society of Clinical Pathology.
Molofsky A.B. and Lu C.M. (2009). Anaplastic Large Cell Lymphoma, Anaplastic Lymphoma Kinase-Positive (ALCL, ALK+). Check Sample, Hematology, American Society of Clinical Pathology.
Swanson M.S., Byrne B.G., Whitfield N.W., Fuse E.T., Tateda K., and Molofsky A.B. (2006). An inflammatory immune response to cytosolic flagellin protects mice from L. pneumophilainfection. Book Chapter in Legionella- Proceedings of the 6th International Conference, Cianciotto, N. et al., eds., ASM Press, Washington DC.
Swanson M.S. and Molofsky A.B. (2005). Autophagy and Inflammatory Cell Death, Partners of Innate Immunity. Review, Autophagy 1(3), 174-6.
Molofsky, A.B., and Swanson, M.S. (2004). Differentiate to thrive: lessons from the Legionella pneumophila life cycle. Mol Microbiol 53, 29–40.r